Pallas
Sermorelin Program

Recovery · Sermorelin

Sermorelin Program

Your body still knows how to make growth hormone. Sermorelin is the signal that tells it to. A clinician-prescribed injection that acts on your pituitary gland the way your own growth hormone-releasing hormone (GHRH) does. 100% online, prescribed only when clinically appropriate by a US-licensed clinician.

Plan, provider care included · Cancel anytime

Sermorelin injection

$139first month

Pay over time —available at checkout
Start your visit

If a clinician decides treatment isn't right for you, you're refunded in full.

  • Signals your pituitary to release your body's own growth hormone
  • May support lean muscle, strength, and recovery as growth hormone declines with age
  • May support body composition, skin, and overall well-being
  • Doctor-led plans, personalized to you
Compounded in the U.S.A.FSA & HSA Eligible

Sermorelin is a synthetic copy of the first 29 amino acids of growth hormone-releasing hormone (GHRH), the signal your brain sends to your pituitary gland. It prompts the pituitary to release your body's own growth hormone, the hormone that drives muscle repair and fat metabolism and that declines steadily through adult life. At Pallas it's prescribed as a compounded subcutaneous injection, only when a US-licensed clinician determines it's clinically appropriate for you.

Sermorelin is prescribed to support your body's own growth hormone release. In small clinical studies of adults with age-related growth hormone decline, GHRH(1-29) and a close analog raised overnight growth hormone and IGF-1, and some participants saw gains in lean mass, some strength measures, skin thickness, insulin sensitivity, and general well-being. Sleep quality did not change in the longest of those trials. The studies were small and short, results vary from person to person, and a US-licensed clinician decides whether sermorelin is appropriate for you.

No. Sermorelin is not growth hormone and is not an HGH replacement. It works upstream, prompting the pituitary gland to release its own growth hormone in pulses, with the body's feedback loops still regulating how much is released. Whether it's appropriate for you is a clinical decision made by a US-licensed clinician.

One price with provider care included, and nothing is charged at checkout. Compounded sermorelin is $139 for your first month, then $199 every 4 weeks, charged once a clinician prescribes, and renews until you cancel. Longer plans lower the average ($139/mo on the annual plan), and a month-to-month plan is available at checkout. If a clinician decides treatment isn't right for you, you're refunded in full.

A man in his forties on a coastal training deck at sunrise, hands on hips after a workout

What is sermorelin

The gland still works. The signal got quiet.

Growth hormone is your body's repair signal. It's released in pulses, and in men about 70% of the day's output comes in the first hours of deep sleep.2 It tells your tissues to build muscle protein and burn stored fat for fuel.1 In healthy men, output falls about 14% with every decade of adult life.3 Here's what most people never hear: the pituitary gland that makes it usually still works. What fades is the signal from the brain telling it to fire.6 Sermorelin is that signal, a synthetic copy of the first 29 amino acids of growth hormone-releasing hormone (GHRH), the part your pituitary actually reads.4

  • Not growth hormone. It prompts your pituitary to release its own4
  • Released in pulses, the way your body already does it5
  • Your body's feedback loops still regulate how much is released5
  • A small subcutaneous injection, with dosing personalized by your clinician

The research

What sermorelin is studied for

Muscle and strength

Growth hormone drives the protein synthesis that rebuilds muscle after you train.1 In studies of older men, GHRH(1‑29) and a close analog raised growth hormone, with gains in lean mass and some strength measures.6,7,8

Your overnight repair window

In men, deep sleep and growth hormone fall together between early adulthood and midlife.9 Sermorelin is not a sleep aid. It's prescribed to support the growth hormone pulse that window is built around.

Body composition and skin

Growth hormone tells your body to burn stored fat for fuel.1 In a 16-week placebo-controlled study, a GHRH analog was linked to thicker skin in men and women, and better insulin sensitivity and well-being in men.7

What it supports

Why do people explore sermorelin therapy?

A man in his late forties curling dumbbells in a sunlit gym

May support lean muscle and strength alongside your training.7,8

A man resting on a gym bench after a workout, towel around his neck

Growth hormone is your repair signal. Sermorelin may support it.1

A man asleep in bed at dawn

In men, about 70% of growth hormone is released in early deep sleep.2

A man in his early fifties running on a coastal trail at sunset

May support body composition, skin, and well-being as growth hormone declines.7

The process

Start your sermorelin program in 3 simple steps

Start online and meet your provider

Step
1

Answer a few questions about your health and goals — about two minutes. A licensed provider reviews everything 100% online.

Hands holding a phone showing the Pallas online intake's goals question

Get your medication delivered to your door

Step
2

If eligible, your provider writes a prescription and medication ships free and discreet from a US-licensed pharmacy — often within a week.

A plain kraft shipping box marked Prescription only

Ongoing support and care, every step

Step
3

We stay with you the whole way, with regular check-ins and on-demand messaging with your care team.

A woman smiling at her phone as a message from her provider asks how she is feeling
Glass medication vials on a pharmacy filling line

Pharmacy & safety

Prescription-only. Pharmacy-prepared.

Every sermorelin plan starts with a US-licensed clinician. If prescribed, your medication is prepared by a state-licensed US compounding pharmacy and shipped free and discreet to your door.

Compounded in state-licensed US pharmacies
Prescribed only when clinically appropriate
Free, discreet shipping

Pallas does not manufacture or compound medication. Compounded medications are prepared by US-licensed compounding pharmacies; the medication you receive may differ in appearance from any product shown on this site.

FAQ

Common questions

Sermorelin is a synthetic copy of the first 29 amino acids of growth hormone-releasing hormone (GHRH), the signal your brain sends to your pituitary gland. It prompts the pituitary to release your body's own growth hormone, the hormone that drives muscle repair and fat metabolism and that declines steadily through adult life. At Pallas it's prescribed as a compounded subcutaneous injection, only when a US-licensed clinician determines it's clinically appropriate for you.

Sermorelin is prescribed to support your body's own growth hormone release. In small clinical studies of adults with age-related growth hormone decline, GHRH(1-29) and a close analog raised overnight growth hormone and IGF-1, and some participants saw gains in lean mass, some strength measures, skin thickness, insulin sensitivity, and general well-being. Sleep quality did not change in the longest of those trials. The studies were small and short, results vary from person to person, and a US-licensed clinician decides whether sermorelin is appropriate for you.

No. Sermorelin is not growth hormone and is not an HGH replacement. It works upstream, prompting the pituitary gland to release its own growth hormone in pulses, with the body's feedback loops still regulating how much is released. Whether it's appropriate for you is a clinical decision made by a US-licensed clinician.

One price with provider care included, and nothing is charged at checkout. Compounded sermorelin is $139 for your first month, then $199 every 4 weeks, charged once a clinician prescribes, and renews until you cancel. Longer plans lower the average ($139/mo on the annual plan), and a month-to-month plan is available at checkout. If a clinician decides treatment isn't right for you, you're refunded in full.

Yes — sermorelin can be prescribed through telehealth in the US when a US-licensed clinician determines it's clinically appropriate for you, and it's prepared by state-licensed US compounding pharmacies. As with any prescription, whether it's suitable depends on your health history — that's why every Pallas plan starts with a clinician review, and certain conditions mean sermorelin isn't an appropriate treatment.

Complete a short online intake about your health and goals. A US-licensed clinician reviews it and, if appropriate, prescribes sermorelin that ships to your door. If a clinician decides treatment isn't right for you, you're refunded in full.

The most commonly reported are brief facial flushing and redness, soreness, or swelling at the injection site. Headache, dizziness, and nausea are reported less often. Tell your clinician about every medication you take, since thyroid medication and glucocorticoids can affect how sermorelin works. Stop and seek medical care right away for signs of an allergic reaction, such as hives, swelling of the face or throat, or trouble breathing.

That's a clinical decision. A US-licensed clinician reviews your health history and goals and determines whether sermorelin is appropriate for you — it isn't right for everyone. Per our clinical partner's prescribing criteria, the program is available to adults 55 and under, and certain conditions (including pregnancy or breastfeeding, active cancer, pituitary disease, untreated hypothyroidism, uncontrolled diabetes, and heart failure) mean it isn't an appropriate treatment.

No. Compounded sermorelin is prepared per-patient by state-licensed US compounding pharmacies and is not FDA-approved. That's exactly why every plan starts with a US-licensed clinician who reviews your health history and prescribes it only when clinically appropriate.

From our members

More from our members

Real feedback from Pallas members across our programs.

“NAD+ therapy gave me a mental clarity I didn't realize I'd been missing — the afternoon fog is gone. I feel sharper, steadier, and more motivated throughout the day.”
Sarah M.Verified member
“Since starting the treatments, I'm sleeping more deeply and waking up with real energy for the first time in a long while. My workouts feel stronger, and recovery doesn't drag on the way it used to.”
Tanya L.Verified member
“After a few weeks of treatments, my skin looked brighter and more even than it has in years. I feel refreshed, and friends keep asking what I've changed.”
Amanda G.Verified member
“The whole process was easier than I expected — a few questions online, and my clinician followed up the same day.”
Sarah M.Verified member
“Shipping was fast and discreet, and the care team actually answers when I message them.”
David R.Verified member
“I never felt rushed. My provider explained every option and let me decide what fit.”
Jenna K.Verified member
“Checking in is simple, refills arrive on time, and support replies within hours.”
Marcus T.Verified member
“From sign-up to delivery, everything just worked the way it should.”
Alicia P.Verified member

Quotes from Pallas members, shared with permission; names abbreviated for privacy. Testimonials reflect individual experiences — individual results vary.

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Sources

Compounded sermorelin is not FDA-approved. The studies below describe growth hormone physiology and small, short trials of GHRH(1-29) and a close analog, mostly in adults over 55. They are not evidence that compounded sermorelin will produce any specific result for you. Sermorelin is prescribed only when clinically appropriate by a US-licensed clinician, and individual results vary.

  1. Møller N, Jørgensen JOL. Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects. Endocr Rev. 2009;30(2):152-177.
  2. Van Cauter E, Plat L, Copinschi G. Interrelations between sleep and the somatotropic axis. Sleep. 1998;21(6):553-566.
  3. Iranmanesh A, Lizarralde G, Veldhuis JD. Age and relative adiposity are specific negative determinants of the frequency and amplitude of growth hormone (GH) secretory bursts and the half-life of endogenous GH in healthy men. J Clin Endocrinol Metab. 1991;73(5):1081-1088.
  4. Prakash A, Goa KL. Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency. BioDrugs. 1999;12(2):139-157.
  5. Walker RF. Sermorelin: a better approach to management of adult-onset growth hormone insufficiency? Clin Interv Aging. 2006;1(4):307-308.
  6. Corpas E, Harman SM, Piñeyro MA, Roberson R, Blackman MR. Growth hormone (GH)-releasing hormone-(1-29) twice daily reverses the decreased GH and insulin-like growth factor-I levels in old men. J Clin Endocrinol Metab. 1992;75(2):530-535.
  7. Khorram O, Laughlin GA, Yen SS. Endocrine and metabolic effects of long-term administration of [Nle27]growth hormone-releasing hormone-(1-29)-NH2 in age-advanced men and women. J Clin Endocrinol Metab. 1997;82(5):1472-1479.
  8. Vittone J, Blackman MR, Busby-Whitehead J, et al. Effects of single nightly injections of growth hormone-releasing hormone (GHRH 1-29) in healthy elderly men. Metabolism. 1997;46(1):89-96.
  9. Van Cauter E, Leproult R, Plat L. Age-related changes in slow wave sleep and REM sleep and relationship with growth hormone and cortisol levels in healthy men. JAMA. 2000;284(7):861-868.